When: 6 September 16:30
Speaker: Maurizio Conti, PET Physics and Reconstruction, Siemens Healthineers
Where: The seminar will take place on Zoom
For more information, please visit: https://indico.cern.ch/e/PET
A brief historical review of time-of-flight (TOF) positron emission tomography (PET) will be presented, including the recent developments in silicon photomultipliers (SiPM), which have resulted in improved TOF performance. The principles of TOF PET physics and a discussion of the technical and clinical advantages of TOF PET compared to conventional PET will be presented, including the concept of time resolution and its effect on TOF gain in signal-to-noise ratio (SNR), as well as properties such as reconstruction robustness to inconsistent data, convergence, and convergence speed. Other advanced reconstruction methods and innovations will be discussed, such as resolution recovery methods, data-driven methods for motion correction and the recent introduction of deep learning in various aspects of PET.
From the hardware point of view, we will review the most recent and exciting developments towards long axial field-of-view – or total-body – PET/CT scanners: design trade-off, characteristics and performance, challenges and advantages, including new applications enabled by very high-performance TOF PET scanners in the field of low-count imaging, theranostics and monoclonal antibody imaging, and dynamic and parametric imaging with simultaneous coverage of multiple organs.
Finally, we will briefly comment on the near future of PET and TOF PET in terms of possible technology developments and the need for fundamental research to push the field forward.
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